First printed in Invasion (2000)
Spreading Plague 
Enchantment
Whenever a creature enters, destroy all other creatures that share a color with it. They can't be regenerated.
MTGO price: 0.8 TIX, the cheapest non-foil print (average sell price on GoatBots, 28 Oct 2026).
In the last 30 days 0.0% of Commander decks played it (1 of 6150). Most played in Sephiroth, Fabled SOLDIER.
Combos
4 combos from Commander Spellbook, the most popular first.
- Destroy all creatures opponents control whenever a creature enters the battlefield, Lock: Eldrazi Monument + Painter's Servant + Spreading Plague
- Destroy all creatures opponents control whenever a creature enters the battlefield, Lock: Darkest Hour + Eldrazi Monument + Spreading Plague
- Lock, Destroy all creatures opponents control whenever a creature enters the battlefield: Avacyn, Angel of Hope + Darkest Hour + Spreading Plague
- Destroy all creatures opponents control whenever a creature enters the battlefield, Lock: Avacyn, Angel of Hope + Painter's Servant + Spreading Plague
Legality
Constructed
- Standard Not legal
- Pioneer Not legal
- Modern Not legal
- Legacy Legal
- Vintage Legal
- Pauper Not legal
- Future Standard Not legal
- Historic Not legal
- Timeless Not legal
- Alchemy Not legal
- Penny Dreadful Not legal
- Premodern Legal
- Old School 93/94 Not legal
Singleton
- Gladiator Not legal
Commander formats
- Commander Legal
- Duel Commander Legal
- Pauper Commander Not legal
- PreDH Legal
- Tiny Leaders Not legal
- Oathbreaker Legal
- Brawl Not legal
- Standard Brawl Not legal
- Competitive Brawl Not legal